Acidic and Basic Groups
Examples of water solubilizing structures and the routes used to introduce them into the lead structures. O-alkylation, N-alkylation, O-acylation and N-acylation reactions are used to introduce both acidic and basic groups. Acetylation methods use both the appropriate acid chloride and anhydride.
Examples of water solubilizing structures and the routes used to introduce them into lead structures. Phosphate acid halides have been used to introduce phosphate groups into lead structures. Structures containing hydroxy groups have been introduced by reaction of the corresponding monochlorinated hydrin and the use of suitable epoxides amongst other methods. Sulphonic acid groups may be introduced by either direct sulfonation or the addition of bisulfite to reactive C = C bonds amongst other methods
Read more about this topic: Molecular Modification
Famous quotes containing the words basic and/or groups:
“When you realize how hard it is to know the truth about yourself, you understand that even the most exhaustive and well-meaning autobiography, determined to tell the truth, represents, at best, a guess. There have been times in my life when I felt incredibly happy. Life was full. I seemed productive. Then I thought,”Am I really happy or am I merely masking a deep depression with frantic activity?” If I don’t know such basic things about myself, who does?”
—Phyllis Rose (b. 1942)
“If we can learn ... to look at the ways in which various groups appropriate and use the mass-produced art of our culture ... we may well begin to understand that although the ideological power of contemporary cultural forms is enormous, indeed sometimes even frightening, that power is not yet all-pervasive, totally vigilant, or complete.”
—Janice A. Radway (b. 1949)