Acidic and Basic Groups
Examples of water solubilizing structures and the routes used to introduce them into the lead structures. O-alkylation, N-alkylation, O-acylation and N-acylation reactions are used to introduce both acidic and basic groups. Acetylation methods use both the appropriate acid chloride and anhydride.
Examples of water solubilizing structures and the routes used to introduce them into lead structures. Phosphate acid halides have been used to introduce phosphate groups into lead structures. Structures containing hydroxy groups have been introduced by reaction of the corresponding monochlorinated hydrin and the use of suitable epoxides amongst other methods. Sulphonic acid groups may be introduced by either direct sulfonation or the addition of bisulfite to reactive C = C bonds amongst other methods
Read more about this topic: Molecular Modification
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