Mochizuki is a Japanese surname. Notable people with the surname include:
- Hisayo Mochizuki
- Kenichi Mochizuki
- Masaaki Mochizuki
- Minoru Mochizuki, martial artist
- Saya Mochizuki, model
- Shigeyoshi Mochizuki
- Shinichi Mochizuki, mathematician
- Sokaku Mochizuki
- Susumu Mochizuki
- Tatsuya Mochizuki
- Tomomi Mochizuki
- Mochizuki Keisuke, cabinet minister in the Taisho and early Showa periods