Science and Technology
- Man-machine interface or user interface
- Modified Mercalli intensity scale, an earthquake intensity measure
- W3C MMI or Multimodal Interaction Activity
- Monolithic Memories, Inc. (1969–1987), an American semiconductor manufacturer
- Motorola Mobility (NYSE: MMI), a publicly traded electronics company, formerly part of Motorola
- Multi Media Interface, an in-car interface system developed by Audi
- Maximum mutual information criterion
- Methimazole, a drug used to treat hyperthyroidism
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