MME may stand for:
- MME (psychedelic), 2,4-dimethoxy-5-ethoxyamphetamine, a psychedelic drug
- Michigan Merit Exam, a minimum-competency test for students
- Mitsubishi Motors Europe, the European subsidiary of Mitsubishi Motors
- Membrane metallo-endopeptidase, an enzyme
- Madam, a married woman
- MME, the IATA code for Durham Tees Valley Airport, England
- Mobility Management Entity, a standardized entity in a System Architecture Evolution network dedicated to mobility management
- Mathematics & Mathematics Education, an academic group of the National Institute of Education, Nanyang Technological University, Singapore
- Multimedia Extensions, an extension to Windows 3.0 to support multimedia
- Midwest Motor Express, a less than truckload freight carrier based in Bismarck, North Dakota, United States