Mizuho (瑞穂) may refer to:
- Places
- Mizuho, Gifu, a city in Gifu
- Mizuho, Tokyo, a town in Tokyo
- Mizuho Township, a town in Hualian County, Taiwan
- Mizuho Plateau in Antarctica
- Mizuho Station (Antarctica)
- People
- Mizuho Sakaguchi, a Japanese association footballer
- Mizuho, a member of the former Japanese band Zone
- Mizuho Fukushima, a Japanese politician
- Fictional characters and places
- Mizuho Kazami, a character in the anime Please Teacher!
- Mizuho Miyanokouji, a character in the game and anime Otome wa Boku ni Koishiteru
- Mizuho, a fictional ninja village in the video game Tales of Symphonia
- Other
- Japanese seaplane carrier Mizuho, a Japanese seaplane carrier
- Mizuho (train), a train service in Japan
- 2090 Mizuho, an asteroid
- Mizuho Financial Group, a Japanese banking conglomerate