Mitogen-activated Protein Kinase
Mitogen-activated protein (MAP) kinases (EC 2.7.11.24) are serine/threonine-specific protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis - among many others.
Read more about Mitogen-activated Protein Kinase: Introduction, Activation, MAP Kinase Cascades, Evolutionary Relationships Among MAP Kinases, Substrate and Partner Recognition, Scaffold Proteins in MAPK Signaling, MAP Kinases As Therapeutic Targets
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