1950
Belleville folded. The team from Springfield, Illinois left the Illinois-Indiana-Iowa League and joined. New teams in Paris, Illinois and Vincennes, Indiana formed and joined the league.
| Centralia Sterlings | 83-40 | |
| West Frankfort Cardinals | St. Louis Cardinals | 72-47 |
| Mattoon Indians | 71-47 | |
| Paducah Chiefs | 67-55 | |
| Springfield Giants | 60-59 | |
| Paris Lakers | 43-75 | |
| Vincennes Citizens | 43-76 | |
| Mount Vernon Kings | 37-77 |
Centralia beat Mattoon 3 games to 1, and Paducah beat West Frankfort 3 games to none, in the first round of the playoffs. The championship series was cancelled due to bad weather.
Read more about this topic: Mississippi-Ohio Valley League