1949
Teams from Belleville, Illinois, Centralia, Illinois, Marion, Illinois, Mattoon, Illinois, Mount Vernon, Illinois, and West Frankfort, Illinois moved from the Illinois State League and joined the league. Mount Vernon moved to Paducah, Kentucky.
| Team Name | Affiliation | Record |
| Centralia Cubs | 74-44 | |
| West Frankfort Cardinals | St. Louis Cardinals | 71-49 |
| Mattoon Indians | 62-56 | |
| Paducah Chiefs | 54-65 | |
| Mount Vernon Kings | 53-67 | |
| Belleville Stags | 43-76 |
Mattoon beat Centralia 3 games to none in the playoffs. Paducah beat West Frankfort by 3 games to none as well. Paducah beat Mattoon 4 games to 3 for the championship.
Read more about this topic: Mississippi-Ohio Valley League