Misao may refer to:
- Misao Fujimura, Japanese philosophy student and poet
- Misao Katagiri, Japanese murderer
- Misao Kusakabe, a fictional character from the Lucky Star manga, anime and video game series
- Makimachi Misao, a fictional character from the Rurouni Kenshin manga and anime series
- Misao, a Kuki tribe of Assam