Mature MiR-21
Pri-miR-21 is cut by the endonuclease Drosha in the nucleus to produce pre-miR-21, which is exported into the cytosol. This pre-miR-21 is then cut in to a short RNA duplex by Dicer in the cytosol. Although abundance of both strands is equal by transcription, only one strand (miR-21) is selected for processing as mature microRNA based on the thermodynamic stability of each end of the duplex, while the other strand (designated with an asterisk; miR-21*) is generally degraded. Mature microRNA is then loaded into microRNA ribonucleoprotein complex RISC (RNA-induced silencing complex) and guided to target mRNAs with near perfect complimentarily at 3’UTR.
Read more about this topic: MIRN21
Famous quotes containing the word mature:
“After mature deliberation of counsel, the good Queen to establish a rule and imitable example unto all posterity, for the moderation and required modesty in a lawful marriage, ordained the number of six times a day as a lawful, necessary and competent limit.”
—Michel de Montaigne (1533–1592)