Mir-7 Micro RNA Precursor - Targets of MiR-7

Targets of MiR-7

Bioinformatic predictions suggest that the human EGFR mRNA 3'-untranslated region contains three microRNA-7 (miR-7) target sites, which are not conserved across mammals. In Drosophila photoreceptor cells, miR-7 controls epidermal growth factor receptor (EGFR) signaling and promotes photoreceptor differentiation. Among other targets of miR-7 are insulin-like growth factor 1 receptor (IGF1R) and PIK3CD, E(spl) gene family and Pak1 (cancer cells). c-Fos is also a target of miR-7b in mice. Pax6 translation in the lateral wall of the subventricular zone of developed mice is post-transcriptionally regulated by miRNA-7a mediated gene silencing, which is necessary to control the rate of dopaminergic neuron production in the olfactory bulb.