Strikeouts
- 2006 - Johan Santana (245)
- 2005 - Johan Santana (238)
- 2004 - Johan Santana (265)
- 1985 - Bert Blyleven (206)*
- 1963 - Camilo Pascual (202)
- 1962 - Camilo Pascual (206)
- 1961 - Camilo Pascual (221)
- * Includes statistics while with Cleveland Indians
Read more about this topic: Minnesota Twins Award Winners And League Leaders, League Leaders, Pitching