Mifsud is a Maltese surname. It may refer to:
- Adrian Mifsud, Maltese footballer
- Anthony J. Mifsud, Maltese-Canadian actor, singer and songwriter
- Carmelo Mifsud Bonnici, Maltese politician, son of Ugo Mifsud Bonnici
- Daniel Mifsud, Australian Idol contestant
- George Mifsud Chircop, linguist
- Immanuel Mifsud, Maltese writer
- Jean Pierre Mifsud Triganza, Maltese footballer
- Josef Mifsud, Maltese footballer
- Karmenu Mifsud Bonnici, former Prime Minister of Malta
- Ludovik Mifsud Tommasi, Maltese priest, educator and poet
- Michael Mifsud, Maltese footballer
- Philip Mifsud, Maltese architect and politician
- Sigmund Mifsud, Maltese musician and conductor
- Stéphane Mifsud, French free-diver
- Steve Mifsud, Australian snooker player
- Ugo Mifsud Bonnici, former President of Malta
- Ugo Pasquale Mifsud, former Prime Minister of Malta
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