Athletics
- Dewon Brazelton – Major League Baseball pitcher
- Mike Caldwell (1993) – former National Football League linebacker
- Tyrone Calico (2002) – former National Football League wide receiver
- Marty Carter (1991) – former National Football League safety
- Alysha Clark (2010) – Women's National Basketball Association forward
- Don Griffin (1986) – former National Football League safety
- James Griffin (1983) – former National Football League safety
- Dwone Hicks (2003) – former National Football League running back
- Kelly Holcomb (1995) – National Football League quarterback
- Amber Holt (2008) – Women's National Basketball Association forward
- ReShard Lee (2003) – National Football League running back
- David Little (1984) – former National Football League tight end
- Kendall Newson (2001) – former National Football League wide receiver
- Ray Oldham (1973) – former National Football League safety
- Jayhawk Owens – former Major League Baseball catcher
- Shane Primm – UFC contestant on The Ultimate Fighter Season 8 Light-Heavyweight Fighter
- Jonathan Quinn (1998) – former National Football League quarterback
- Mardy Scales (2003) – United States sprinter
- Dwight Stone (1986) – former National Football League wide receiver
- Kenny Tippins (1989) – former National Football League linebacker
- Ken Trickey (1955) – college basketball coach
- Erik Walden (2008) – National Football League linebacker
Read more about this topic: Middle Tennessee State University Alumni