Target Genes
MITF recognizes E-box (CAYRTG) and M-box (TCAYRTG or CAYRTGA) sequences in the promoter regions of target genes. Known target genes (confirmed by at least two independent sources) of this transcription factor include,
|
ACP5 |
BCL2 |
BEST1 |
BIRC7 |
|
CDK2 |
CLCN7 |
DCT |
EDNRB |
|
GPNMB |
GPR143 |
MC1R |
MLANA |
|
OSTM1 |
RAB27A |
SILV |
SLC45A2 |
|
TBX2 |
TRPM1 |
TYR |
TYRP1 |
Additional genes identified by a microarray study (which confirmed the above targets) include the following,
| MBP | TNFRSF14 | IRF4 | RBM35A |
| PLA1A | APOLD1 | KCNN2 | INPP4B |
| CAPN3 | LGALS3 | GREB1 | FRMD4B |
| SLC1A4 | TBC1D16 | GMPR | ASAH1 |
| MICAL1 | TMC6 | ITPKB | SLC7A8 |
Read more about this topic: Microphthalmia-associated Transcription Factor
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