MHS may refer to:
- Air Memphis, and Egyptian airline that uses the ICAO-Code MHS
- Malignant hyperthermia syndrome, a condition that is triggered by exposure to drugs used for general anaesthesia
- Master of Health Science, a graduate degree program
- Meadowhall Interchange, a railway station in England that uses the National Rail station code MHS
- RAF Menwith Hill, also known as Menwith Hill Station (MHS), a Royal Air Force station in Harrogate, North Yorkshire
- Message Handling System, a past Novell email protocol
- Michigan Humane Society, an organization providing animal welfare and sheltering services
- Microwave Humidity Sounder, an Earth-observing instrument on NOAA POES and EUMETSAT MetOp satellites
- Military Health System, the United States Department of Defense health care system
- Museum of the History of Science, a museum in Oxford, England
- Mean Hamster Software, a video game developer based in Deer Park, Washington, USA
- Mull Historical Society, a Scottish indie rock band
- Montana Historical Society
Read more about MHS: Schools