MFR may refer to:
- Manufacturer
- Marine Forces Reserve
- Mass flow rate
- Medical first responder
- Member of the Order of the Federal Republic, one of the Nigerian National Honours
- Memorandum for record
- Methanofuran
- Minimum funding requirement
- Mobile field reporting
- Moray Firth Radio, a Scottish commercial radio station based in Inverness
- Multi-frequency receiver
- Multifunction radar
- Multilink Frame Relay, a CISCO implementation
- Music for Relief, a charity organisation founded by Linkin Park
- Myofascial release
- Rogue Valley International-Medford Airport