Mexican Federal Highway 180 is a Mexican Federal Highway that follows Mexico's Gulf and Caribbean Coast from the Mexico-U.S. border at Brownsville, Texas, into Matamoros, Tamaulipas, to the resort city of Cancún, Quintana Roo, in the Yucatán Peninsula. Although the highway is numbered as an east-west route, it initially follows a north-south alignment through Tamaulipas and Veracruz.
The highway is briefly interrupted from El Encinal to Soto la Marina in Tamaulipas just north of Tampico. The highway goes through Tampico south, interrupted briefly from Cerro Azul to Potrero del Llano, to the city of Poza Rica. It continues south from there through Veracruz and Coatzacoalcos. From there it goes east into Villahermosa, north through Campeche into Mérida, and finally east into Cancún.
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