History
In April 1944, Eli Lilly and Company trademarked methylhexanamine, as Forthane, for potential use as a nasal decongestant. Forthane was also patented as a nasal decongestant and a treatment for hypertrophied or hyperplasic oral tissues Aside from patent applications, methylhexanamine use is not mentioned in historical medical literature, and no medical use of methylhexanamine is recognized today. The trademark for Forthane has since expired. Methylhexanamine should not be confused with isoflurane, a general inhalation anaesthetic, which has the proprietary name in Australia of Forthane.
Patrick Arnold reintroduced methylhexanamine in 2006 as a dietary supplement, after the final ban of ephedrine as a dietary supplement in the United States in 2005. Arnold introduced it under the trademarked name Geranamine, a name held by his company, Proviant Technologies. A large number of supplements focusing on fat loss and workout energy now use the ingredient in concert with other substances such as caffeine, a combination similar to the combination of ephedrine and caffeine; the former ingredient is now banned in a number of countries.
A 2012 Dutch literature study on the regulatory status of methylhexamine concluded that food supplements with > 4 mg methylhexamine are pharmacologically effective and therefore require licensing as a medicine. The authors deduce that oral methylhexamine acts as a bronchodilator (above 4 mg), increases heart rate (above 50–75 mg), and increases blood pressure (above 100 mg). Serious adverse effects are expected for oral dosages above 200 mg.
Read more about this topic: Methylhexanamine
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