Methoxyflurane - Chemical and Physical Properties

Chemical and Physical Properties

Further information: Organofluorine

With a molecular formula of C3H4Cl2F2O and a condensed structural formula of CHCl2CF2OCH3, the International Union of Pure and Applied Chemistry (IUPAC) name for methoxyflurane is 2,2-dichloro-1,1-difluoro-1-methoxyethane. It is a halogenated ether in form of a clear, colorless liquid, and its vapor has a strong fruity aroma. It is miscible with ethanol, acetone, chloroform, diethyl ether, and fixed oils. It is soluble in rubber.

With a minimum alveolar concentration (MAC) of 0.2%, methoxyflurane is an extremely potent anesthetic agent. It is a powerful analgesic agent at well below full anesthetic concentrations. Because of its low volatility and very high boiling point (104.8 °C at 1 atmosphere), methoxyflurane has a low vapor pressure at ambient temperature and atmospheric pressure. It is therefore quite difficult to vaporize methoxyflurane using conventional anesthetic vaporizers.

Property Value
Boiling point (at 1 atmosphere) 104.8 °C
Minimum alveolar concentration (MAC) 0.2
Vapor pressure (mmHg at 20 °C) 22.5
Partition coefficient (Blood:Gas) 12
Partition coefficient (Oil:Gas) 950
Partition coefficient (Oil:Water) 400
Specific gravity at 25 °C 1.42
Flash point 63 °C
Molecular weight (g mol−1) 164.97
Vapor-liquid equilibrium (mL) 208
Flammability limits 7% in air
Chemical stabilizer necessary Yes

The carbon–fluorine bond, a component of all organofluorine compounds, is the strongest chemical bond in organic chemistry. Furthermore, this bond becomes shorther and stronger as more fluorine atoms are added to the same carbon on a given molecule. Because of this, fluoroalkanes are some of the most chemically stable organic compounds.

Read more about this topic:  Methoxyflurane

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