Mechanism of Action
The product of the cleavage of the carbamate group of methiocarb is methylcarbamic acid which is bound to choline sterase after the reaction. The normal function of choline sterase is to cleave the acetyl-choline bond which results in the binding of acetic acid to choline sterase which is a fast reversible reaction. The carbamic acid also reversibly binds but the hydrolysis of the bond is slower and therefore the acid inhibits the function of choline sterase which results in elevated choline sterase levels. In comparison: organophosphates inhibit irriversibly and will therefore inhibit the acetylcholinesterase even more.
Read more about this topic: Methiocarb
Famous quotes containing the words mechanism of, mechanism and/or action:
“A mechanism of some kind stands between us and almost every act of our lives.”
—Sarah Patton Boyle, U.S. civil rights activist and author. The Desegregated Heart, part 3, ch. 2 (1962)
“When one of us dies of cancer, loses her mind, or commits suicide, we must not blame her for her inability to survive an ongoing political mechanism bent on the destruction of that human being. Sanity remains defined simply by the ability to cope with insane conditions.”
—Ana Castillo (b. 1953)
“Not rarely, and this is especially true of wives and mothers, the motive behind assuming a disproportionate share of work and responsibility is completely unselfish. We want to protect, to spare those of whom we are fond. We forget that, regardless of the motive, the results of such action are almost always destructive and unproductive.”
—Hortense Odlum (1892–?)