Mechanism of Action
The product of the cleavage of the carbamate group of methiocarb is methylcarbamic acid which is bound to choline sterase after the reaction. The normal function of choline sterase is to cleave the acetyl-choline bond which results in the binding of acetic acid to choline sterase which is a fast reversible reaction. The carbamic acid also reversibly binds but the hydrolysis of the bond is slower and therefore the acid inhibits the function of choline sterase which results in elevated choline sterase levels. In comparison: organophosphates inhibit irriversibly and will therefore inhibit the acetylcholinesterase even more.
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