Distribution
To determine the distribution of methiocarb through the body carbon-14 labeled methiocarb studies have been performed on rats. About 8 hours after IP injection of methiocarb more than 20 is present in the kidneys, 14 in the lungs, 14 in the heart, 6 in the body fat and 26 in the red blood cells. All the numbers are a measure of the radioactivity in dpm x 103/g of dried tissue. 30 Minutes after treatment gave, for all tissues except bodyfat, much higher values indicating that elimination takes place shortly after injection. Also an increase in all tissues except the red blood cells has been observed between 2 and 4 hours after injection. This indicates that after two hours redistribution takes place shortly followed by elimination. This radioactivity study only measured the so the compound could already be metabolized to different compounds with different toxicities, which is not indicated in this study.
Read more about this topic: Methiocarb
Famous quotes containing the word distribution:
“Classical and romantic: private language of a family quarrel, a dead dispute over the distribution of emphasis between man and nature.”
—Cyril Connolly (1903–1974)
“The question for the country now is how to secure a more equal distribution of property among the people. There can be no republican institutions with vast masses of property permanently in a few hands, and large masses of voters without property.... Let no man get by inheritance, or by will, more than will produce at four per cent interest an income ... of fifteen thousand dollars] per year, or an estate of five hundred thousand dollars.”
—Rutherford Birchard Hayes (1822–1893)
“The man who pretends that the distribution of income in this country reflects the distribution of ability or character is an ignoramus. The man who says that it could by any possible political device be made to do so is an unpractical visionary. But the man who says that it ought to do so is something worse than an ignoramous and more disastrous than a visionary: he is, in the profoundest Scriptural sense of the word, a fool.”
—George Bernard Shaw (1856–1950)