Metabolic Control Analysis - Control Coefficients

Control Coefficients

A control coefficient measures the relative steady state change in a system variable, e.g. pathway flux (J) or metabolite concentration (S), in response to a relative change in a parameter, e.g. enzyme activity or the steady-state rate of step i. The two main control coefficients are the flux and concentration control coefficients. Flux control coefficients are defined by:

and concentration control coefficients by:

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