Meta-analysis - Steps in A Meta-analysis

Steps in A Meta-analysis

1. Formulation of the problem

2. Search of literature

3. Selection of studies ('incorporation criteria')

  • Based on quality criteria, e.g. the requirement of randomization and blinding in a clinical trial
  • Selection of specific studies on a well-specified subject, e.g. the treatment of breast cancer.
  • Decide whether unpublished studies are included to avoid publication bias (file drawer problem)

4. Decide which dependent variables or summary measures are allowed. For instance:

  • Differences (discrete data)
  • Means (continuous data)
  • Hedges' g is a popular summary measure for continuous data that is standardized in order to eliminate scale differences, but it incorporates an index of variation between groups:
in which is the treatment mean, is the control mean, the pooled variance.

5. Model selection (see next paragraph)

For reporting guidelines, see the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement

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