Merlin (protein)

Merlin (protein)

Identifiers Symbols NF2; ACN; BANF; SCH External IDs OMIM: 607379 MGI: 97307 HomoloGene: 2180 GeneCards: NF2 Gene

Gene Ontology
Molecular function protein binding
cytoskeletal protein binding
Cellular component nucleus
early endosome
plasma membrane
adherens junction
extrinsic to membrane
cortical actin cytoskeleton
filopodium membrane
cleavage furrow
ruffle membrane
perinuclear region of cytoplasm
Biological process mesoderm formation
negative regulation of cell-matrix adhesion
negative regulation of protein kinase activity
ectoderm development
negative regulation of DNA replication
negative regulation of cell proliferation
Schwann cell proliferation
negative regulation of cell-cell adhesion
actin cytoskeleton organization
negative regulation of cell migration
regulation of hippo signaling cascade
odontogenesis of dentin-containing tooth
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of MAPK cascade
cell-cell junction organization
negative regulation of JAK-STAT cascade
positive regulation of stress fiber assembly
lens fiber cell differentiation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4771 18016 Ensembl ENSG00000186575 ENSMUSG00000009073 UniProt P35240 P46662 RefSeq (mRNA) NM_000268.3 NM_001252250.1 RefSeq (protein) NP_000259.1 NP_001239179.1 Location (UCSC) Chr 22:
30 – 30.09 Mb Chr 11:
4.77 – 4.85 Mb PubMed search

Merlin (also called Neurofibromin 2 or schwannomin) is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein family.

The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein".

Read more about Merlin (protein):  Gene, Structure, Function, Interactions

Other articles related to "merlin, protein":

Merlin (protein) - Interactions
... Merlin(protein has been shown to interact with HGS, CUL4A, EZR, SDCBP, VPRBP, RIT1, SPTBN1, MED28 and DDB1 ...

Famous quotes containing the word merlin:

    Of Merlin wise I learned a song,—
    Sing it low, or sing it loud,
    It is mightier than the strong,
    And punishes the proud.
    Ralph Waldo Emerson (1803–1882)