Signs and Symptoms
MCC usually presents as a firm, painless, nodule (up to 2 cm diameter) or mass (>2 cm diameter). These flesh-colored, red, or blue tumors typically vary in size from 0.5 cm (less than one-quarter of an inch) to more than 5 cm (2 inches) in diameter, and usually enlarge rapidly. Although MCC's may arise almost anywhere on the body, about half originate on sun-exposed areas of the head and neck, one-third on the legs, and about one-sixth on the arms. In about 12% of cases, no obvious anatomical site of origin ("primary site") can be identified.
Merkel cell cancers tend to invade locally, infiltrating the underlying subcutaneous fat, fascia, and muscle, and typically metastasize early in their natural history, most often to the regional lymph nodes. MCC's also spread aggressively through the blood vessels, particularly to liver, lung, brain, and bone.
Read more about this topic: Merkel Cell Carcinoma
Famous quotes containing the words signs and, signs and/or symptoms:
“But I will harden Pharaoh’s heart, and I will multiply my signs and wonders in the land of Egypt.”
—Bible: Hebrew, Exodus 7:3.
“It is one of the signs of the times. We confess that we have risen from reading this book with enlarged ideas, and grander conceptions of our duties in this world. It did expand us a little.”
—Henry David Thoreau (1817–1862)
“The human condition is such that pain and effort are not just symptoms which can be removed without changing life itself; they are the modes in which life itself, together with the necessity to which it is bound, makes itself felt. For mortals, the “easy life of the gods” would be a lifeless life.”
—Hannah Arendt (1906–1975)