Meningococcal Vaccination and People With Chronic Medical Conditions
Persons with component deficiencies in the final common complement pathway (C3,C5-C9) are more susceptible to N. meningitidis infection than complement-satisfactory persons, and it was estimated that the risk of infection is 7000 times higher in such individuals. In addition, complement component-deficient population frequently experience frequent meningococcal disease since their immune response to natural infection may be less complete than that of complement none-deficient persons.
Inherited properdin deficiency also is related with an increased risk of contracting meningococcal disease. Because persons with functional or anatomic asplenia may not immune to efficiently clear encapsulated Neisseria meningitidis from the bloodstream Persons with other conditions associated with immunosuppression also may be at increased risk of developing meningitis disease.
Read more about this topic: Meningococcal Disease
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