Meltdown may refer to:
- Nuclear meltdown
- Subprime mortgage crisis
- Meltdown (book), a 2009 book on the 2008 financial crisis by economist Thomas Woods
- Mutational meltdown in population genetics
- A tantrum
- Meltdown (Image Comics), a two-part comic book mini-series
- Tabitha Smith, a Marvel Comics character who was a member of the New Mutants and X-Force under the names Boom Boom, Boomer and Meltdown
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