Mella can refer to:
- Mella, a river in North Italy
- Edoardo Arborio Mella (1808–1884), an Italian architect
- Julio Antonio Mella, one of the founders of the "internationalized" Cuban Communist Party
- Mella, Cuba, a municipality in Santiago de Cuba Province, Cuba
- Mella (Golgafrinchan), a character from The Hitchhiker's Guide to the Galaxy by Douglas Adams