Melisende was a popular French name in the Middle Ages, and may refer to:
- Melisende of Jerusalem, Queen of Jerusalem
- Melisende of Montlhéry, grandmother of Melisende of Jerusalem
- Melisende of Tripoli, niece of Melisende of Jerusalem
- Melisende of Lusignan, great-granddaughter of Melisende of Jerusalem
- Melisende of Arsuf
- Melisende of Piquigny