Meldrum is a surname, and may refer to:
- Andrew Meldrum (born 1951), American reporter
- Andrew Norman Meldrum (1876–1934), Scottish scientist
- Colin Meldrum (born 1975), Scottish footballer
- Courtney Meldrum (born 1977), American long-distance runner
- Glenn Meldrum (born 1986), Australian actor
- Molly Meldrum (born 1943), Australian media personality also known as Ian Meldrum
- Jeffrey Meldrum (born 1958), American anthropologist
- Sir John Meldrum (died 1645), a soldier of Scottish origin who spent 36 years in the service of the Stuart kings of Scotland and England, James VI and I and Charles I.
- John W. Meldrum (died 1936), 1st U.S. Commissioner, Yellowstone National Park
- Keith Meldrum (20th century), British veterinarian
- Max Meldrum (1875–1955), Australian painter
- Michael Meldrum (born 1968), Canadian swimmer
- Michelle Meldrum (1968–2008), American guitarist
- Molly Meldrum (1943- ), Australian musician
- Norman H. Meldrum (19th century), American politician
- Paul Meldrum (born 1960), Australian rules footballer
- Wendel Meldrum (born 1958), Canadian actress
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