Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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—Herman Melville (1819–1891)