Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“Look into the world—how often do you behold a sordid wretch, whose straight heart is open to no man’s affliction, taking shelter behind an appearance of piety, and putting on the garb of religion, which none but the merciful and compassionate have a title to wear.”
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