Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“The aim of science is to apprehend this purely intelligible world as a thing in itself, an object which is what it is independently of all thinking, and thus antithetical to the sensible world.... The world of thought is the universal, the timeless and spaceless, the absolutely necessary, whereas the world of sense is the contingent, the changing and moving appearance which somehow indicates or symbolizes it.”
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