Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“To educate the wise man, the State exists; and with the appearance of the wise man, the State expires. The appearance of character makes the state unnecessary. The wise man is the State.”
—Ralph Waldo Emerson (1803–1882)