Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“The actor is too prone to exaggerate his powers; he wants to play Hamlet when his appearance is more suitable to King Lear.”
—Sarah Bernhardt (1845–1923)