Histologic Appearance
On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
The histologic differential diagnosis of mucosal pigmentation is: lipofuscin (melanosis coli), hemosiderin-laden macrophages, and melanin (rare).
Read more about this topic: Melanosis Coli
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“This mesa plain had an appearance of great antiquity, and of incompleteness; as if, with all the materials for world-making assembled, the Creator had desisted, gone away and left everything on the point of being brought together, on the eve of being arranged into mountain, plain, plateau. The country was still waiting to be made into a landscape.”
—Willa Cather (1873–1947)