Number of Combinations
Both versions of the puzzle have 20 corners and 30 edges. In both cases, only even permutations are possible, regardless of the position of the other set of pieces. Thus, while it is possible to have two corners and two edges swapped on a Rubik's Cube, this is impossible on the Megaminx. There are 20!/2 ways to arrange the corners and 319 ways to orient them, since the orientation of the last corner depends on that of the preceding ones. There are 30!/2 ways to arrange the edges and 229 ways to flip them.
The full number is 100 669 616 553 523 347 122 516 032 313 645 505 168 688 116 411 019 768 627 200 000 000 000 (roughly 101 unvigintillion on the short scale or 101 undecillion on the long scale).
The corners are distinguishable on a six-color Megaminx because two corners with the same three colors will be mirror images of each other. There are 15 pairs of identical edges. It would not be possible to swap all 15 pairs, since this would be an odd permutation of the edges, so a reducing factor of 214 is applied to the preceding figure.
The full number is 6 144 385 775 971 883 979 645 753 925 393 402 415 081 061 792 664 780 800 000 000 000 (roughly 6.1 vigintillion on the short scale or 6.1 decilliard on the long scale).
Read more about this topic: Megaminx
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—Fred Rogers (20th century)