Operators
- Belgium
- Federal Police
- Gendarmerie (Belgium) – Former operator
- Noordzee Helikopters Vlaanderen Operates 4 MD Explorer Units
- Germany
- Baden-Württemberg State Police (6 MD Explorer Units)
- Lower Saxony Police
- Deutsche Rettungsflugwacht German Air Ambulance
- Luxembourg
- Luxembourg Air Rescue
- Luxembourg Police
- Mexico
- Mexican Navy
- Search & Rescue Unit
- United Kingdom
- Cambridgeshire Police
- Dorset Police
- Essex Air Ambulance
- Great North Air Ambulance
- Greater Manchester Police
- Hertfordshire Air Ambulance
- Humberside Police
- Kent Air Ambulance
- Lincolnshire & Nottinghamshire Air Ambulance
- London Air Ambulance
- South Yorkshire Police
- Surrey and Sussex Air Ambulance
- Sussex Police
- Trinity House (English & Welsh General Lighthouse Authority)
- West Yorkshire Police
- Wiltshire Police/Air Ambulance
- Yorkshire Air Ambulance
- United States
- United States Coast Guard (Replaced by the MH-65C)
- Drug Enforcement Administration
- National Park Service
- Western Pennsylvania Hospital
- Calstar
- Cox Air Care
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