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- Marvel Cinematic Universe, A shared fictional universe of superhero films developed by Marvel Studios based on characters published in Marvel Comics much like the Marvel Universe in comic books.
- The (fictional) Major Crimes Unit of the Gotham City Police Department in the Batman series of comic books; and the agency of the Chicago Police Department in the TV Series Crime Story; the term recurred again in the movie Heat, as the Unit from which Lt. Vincent Hanna (Al Pacino) takes down Neil McCauley (Robert De Niro) and his crew
- The IATA airport code for Montluçon - Guéret Airport in France
- Main control unit
- MCU (artist), Japanese HipHop/Rap artist, formerly member of Kick the Can Crew; currently working as solo artist
- material change of use Material change of use is a term the State Government of Queensland (Australia) and Queensland local governments use in the assessment of property development applications. It is defined in the Queensland Government's Integrated Planning Act 1997 (IPA) as:
- the start of a new use of the premises; - the re-establishment on the premises of a use that has been abandoned, or - a material change in the intensity or scale of the use of the premises.
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