Filming Locations
The interior set of the McMillans' home in the pilot episode was actually Rock Hudson's house. In the second episode they moved to a new home, exterior shots were done on Greenwich Street in San Francisco. The address for the couple was once given in the show as 250 Carson Street. In later episodes a different house was used as the exterior shot of the house. In the final season McMillan, newly widowed, moved into an apartment and the house was never seen or mentioned again.
Read more about this topic: McMillan & Wife