McDuff is a surname. It is the Anglicized form of the Gaelic name Mac Dhuibh (Mac = son, Dhuibh = dark/black).
People named McDuff:
- David McDuff, Scottish literary translator
- Dusa McDuff, English mathematician
- Jack McDuff (1926-2001), American Jazz musician
- Kenneth McDuff (1946-1998), American serial killer
Fictional characters:
- McDuff, the Talking Dog, a children's television character
- Suds McDuff, another name for The Simpsons' dog Santa's Little Helper
- Father Cyril McDuff, a priest in the television series Father Ted
Other usage:
- McDuff, California, former town in Humboldt County
- Gritty McDuff's Brewing Company, a brewery in Maine, USA
- McDuff Electronics, a defunct subsidiary of Tandy Corporation