McBain may refer to:
- Clan MacBain, a highland Scottish clan
- Diane McBain (born 1941), American actress
- Ed McBain (1926–2005), American author and screenwriter
- McBain, a character played by fictional actor Rainier Wolfcastle on The Simpsons
- McBain (film), a 1991 action film written and directed by James Glickenhaus
- McBain, Michigan, a city in Missaukee County in the U.S. state of Michigan
- Scott McBain (born 1960), Scottish fiction author