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- James MacDonnell (1884–1973), Canadian soldier, lawyer, and politician from Ontario
- James MacKerras Macdonnell (1884–1973), Canadian lawyer and parliamentarian from Ontario
- James Macdonnell (1781–1857), Scottish military officer; fought at the Battle of Waterloo
- James Smith McDonnell (1899–1980), American businessman and aviation pioneer; founder of McDonnell Aircraft, later McDonnell-Douglas
- Joe McDonnell (ice hockey) (born 1961), Canadian professional ice hockey player
- Joe McDonnell (rugby player) (born 1973), New Zealand rugby union player
- Joe McDonnell (hunger striker) (1951–1981), Irish member of the Provisional IRA; died in IRA hunger strike
- John McDonnell (businessman) (born 1938), American aviation businessman, son of James Smith McDonnell
- John McDonnell (coach) (born 1938), Irish-American college football coach
- John McDonnell (footballer) (born 1965), Irish football manager
- John McDonnell (politician) (born 1951), British politician and MP
- Johnny McDonnell (fl. early 20th c.), Irish footballer
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