Selected Ion Monitoring Chromatogram
A selected ion monitoring (SIM) chromatogram is similar to an XIC, with the exception that the mass spectrometer is operated in SIM mode, such that only a selected m/z value (or more) is/are detected in the analysis. SIM experiments can be performed using mass spectrometry (MS) or tandem mass spectrometry (MS/MS) instruments. They are more common on MS instruments. This differs significantly from the Extracted Ion Chromatogram mentioned above in that only data for the ion(s) of interest are collected in a SIM experiment; for extracted-ion chromatograms, data for an entire mass range are collected during the run and then examined for analytes of interest after the completion of the run.
Read more about this topic: Mass Chromatogram
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