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- Samuel Jefferson Mason, American electrical engineer
- Sarah Mason, several people
- Scott Mason, Australian cricketer
- Simon Mason, English field hockey goalkeeper
- Skookum Jim Mason (c. 1855 – 1916), Klondike gold rush
- Spinner Mason, a fictional character in Degrassi: The Next Generation
- Steve Mason (disambiguation), several people
- Stevens Thomson Mason (Virginia) (1760–1803), US Senator
- Stevens T. Mason (1811–1843), Governor of Michigan, grandson of the Governor of Virginia
- Sylvia Mason-James, British singer
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