Masini is an Italian surname, may refer to:
- Alfred Masini (1930–2010), American television producer
- Donna Masini, American poet and novelist
- Francesco Masini (1894–1964), Maltese lawyer and politician
- Galliano Masini (1896–1986), Italian operatic tenor
- Gerardo Masini, (born 1982), Argentine footballer
- Girolamo Masini (1840–1885), Italian sculptor
- Marco Masini (born 1964), Italian singer-songwriter
- Simone Masini (born 1984) Italian footballer
- Tobia Masini (born 1976), Italian auto racing driver
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