Marchetti is a surname of Italian origin. The name may refer to:
- Alberto Marchetti (b. 1954), Italian professional football player
- Alessandro Marchetti (1884–1966), Italian aircraft engineer
- Alessandro Marchetti (1633–1714), Italian mathematician
- Elio Marchetti (b. 1974), Italian race car driver and motorcycle racer
- Federico Marchetti (b. 1983), Italian international football goalkeeper
- Filippo Marchetti (1831–1902), Italian opera composer
- Gino Marchetti (b. 1927), American professional football player
- Louis Marchetti (1920–1992), Italian illustrator and portrait painter
- Marco Marchetti (1528–1588), Italian painter of the late-Renaissance or Mannerist period
- Victor Marchetti (b. 1930), American intelligence agent and director in the CIA