Other Relevant Clinical Information
M. perstans might potentially interfere with the host's regulatory mechanisms and influence the outcome of other infections, such as malaria, tuberculosis and HIV, which often thrive in similar environments.
Recent research has also focused on coinfection of M. perstans and other filarial parasites. A study examining the epidemiology of Loa loa, Onchocerca voluvulus, and M. perstans in the rain forest villages of Cameroon found a high prevalence of coinfection with O. voluvulus and M. perstans. It also found a low prevalence of L. loa and O. voluvulus coinfection, as well as low prevalence of L. loa and M. perstans coinfection. Coinfection also has singficant implications for treatment, because efficacious drugs for M. perstans are different from those for most filarial infections.
Another study evaluated the effectiveness of ivermectin and albendazole in M. perstans and Wuchereria bancrofti coinfection in a filarial endemic region of Mali, finding that M. perstans infection did not have a significant effect on the treatment of W. bancrofti. Other studies have evaluated the efficacy of other treatments on co-infection with other filarial parasites and M. perstans.
Read more about this topic: Mansonella Perstans
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