Function
Early in the Golgi, the oligosaccharide chains of lysosomal hydrolases are tagged with terminal phosphomannosyl moieties. The lysosomal hydrolases continue through the Golgi and encounter MPRs at the TGN.
At the TGN, MPR-ligand complexes interact with the heterotetrameric complex of the AP1 clathrin adaptor complex and/or members of the GGA family of clathrin adapters. Binding concentrates receptor-ligand complexes into tubular structures at the TGN and they are packaged into clathrin-coated vesicles. These vesicles are very dynamic and live-cell video microscopy shows that they fuse with early endosomes that are positive for internalized transferrin. MPRs are then segregated from transferrin within early endosomes, yielding two distinct domains.
Read more about this topic: Mannose 6-phosphate Receptor
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