Mamie may refer to:
People:
- Mamie Cadden (1891–1959), an Irish midwife, backstreet abortionist and convicted murderer
- Mamie Clark (1917–1983), African American psychologist
- Mary Dickens (1838–1896), daughter of Charles Dickens
- Mamie Eisenhower (1896–1979), wife of President Dwight D. Eisenhower
- Mamie Eva Keith (1873–1986), American supercentenarian
- Mamie Gummer (1983–), American actress
- Mamie Johnson (1935–), first female pitcher in the Negro Leagues
- Mamie Jones, a pseudonym of Aileen Stanley (1897–1982), a popular American singer
- Mary "Mamie" Lincoln (1869–1938), granddaughter of Abraham Lincoln
- Mamie Locke (1954–), Democratic member of the Virginia Senate
- Mamie Smith (1883–1946), American vaudeville singer, dancer, pianist and actress
- Mamie Thurman (1901–1932), American murder victim
- Mamie Van Doren (1931–), American actress and sex symbol
Fictional characters:
- Mamie Dubcek, from the NBC sitcom 3rd Rock from the Sun
- Mamie Johnson, character in the CBS soap opera The Young and the Restless
- Mamie Stover, a character in a 1951 novel by William Bradford Huie
Other uses:
- Typhoon Mamie:
- a 1957 typhoon
- a 1982 tropical storm
- a 1985 typhoon