Calculating The Maintenance Dose
The required maintenance dose may be calculated as:
Where:
-
MD is the maintenance dose rate Cp = desired peak concentration of drug CL = clearance of drug in body F = bioavailability
For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.
Read more about this topic: Maintenance Dose
Famous quotes containing the words calculating the, calculating, maintenance and/or dose:
“What our children have to fear is not the cars on the highways of tomorrow but our own pleasure in calculating the most elegant parameters of their deaths.”
—J.G. (James Graham)
“Because relationships are a primary source of self-esteem for girls and women, daughters need to know they will not lose our love if they speak up for what they want to tell us how they feel about things. . . . Teaching girls to make specific requests, rather than being indirect and agreeable, will help them avoid the pitfalls of having to be manipulative and calculating to get what they want.”
—Jeanne Elium (20th century)
“... in the fierce competition of modern society the only class left in the country possessing leisure is that of women supported in easy circumstances by husband or father, and it is to this class we must look for the maintenance of cultivated and refined tastes, for that value and pursuit of knowledge and of art for their own sakes which can alone save society from degenerating into a huge machine for making money, and gratifying the love of sensual luxury.”
—Mrs. H. O. Ward (1824–1899)
“When a mother quarrels with a daughter, she has a double dose of unhappiness—hers from the conflict, and empathy with her daughter’s from the conflict with her. Throughout her life a mother retains this special need to maintain a good relationship with her daughter.”
—Terri Apter (20th century)