Calculating The Maintenance Dose
The required maintenance dose may be calculated as:
Where:
-
MD is the maintenance dose rate Cp = desired peak concentration of drug CL = clearance of drug in body F = bioavailability
For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.
Read more about this topic: Maintenance Dose
Famous quotes containing the words calculating the, calculating, maintenance and/or dose:
“[The] elderly and timid single gentleman in Paris ... never drove down the Champs Elysees without expecting an accident, and commonly witnessing one; or found himself in the neighborhood of an official without calculating the chances of a bomb. So long as the rates of progress held good, these bombs would double in force and number every ten years.”
—Henry Brooks Adams (18381918)
“I know that the right kind of leader for the Labour Party is a kind of desiccated calculating machine.”
—Aneurin Bevan (18971960)
“My course is a firm assertion and maintenance of the rights of the colored people of the South according to the Thirteenth, Fourteenth, and Fifteenth Amendments, coupled with a readiness to recognize all Southern people, without regard to past political conduct, who will now go with me heartily and in good faith in support of these principles.”
—Rutherford Birchard Hayes (18221893)
“Whipping and abuse are like laudanum: you have to double the dose as the sensibilities decline.”
—Harriet Beecher Stowe (18111896)