Surname
- James Madison, fourth President of the United States
- Dolley Madison, the wife of James Madison
- George Madison, the Governor of Kentucky
- Guy Madison, an actor
- Helene Madison, a swimmer
- Holly Madison, an American model
- James Madison (bishop), the first bishop of the Episcopal Diocese of Virginia, the eighth president of the College of William and Mary, a cousin of the President of the United States (James Madison)
- James G. Madison, known as the Mad Hatter (bank robber), a convicted bank robber in New Jersey
- James Jonas Madison, a U.S. Navy commander
- James Madison, Sr., the father of the American President
- Joe Madison, a political activist
- Kelly Madison, a pornographic film actress
- Lucy Foster Madison, a United States novelist (See "Madison, Lucy Foster". Encyclopedia Americana. 1920.)
- Martha Madison, an actress
- Sam Madison, an American football player
- Talia Madison, an alternate ring name of American professional wrestler Jamie Szantyr (born 1981), best known as Velvet Sky
- Tianna Madison, an American athlete
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