MAD2L2

MAD2L2

Identifiers Symbols MAD2L2; MAD2B; POLZ2; REV7 External IDs OMIM: 604094 MGI: 1919140 HomoloGene: 4624 GeneCards: MAD2L2 Gene

Gene Ontology
Molecular function	• RNA polymerase II activating transcription factor binding • protein binding • JUN kinase binding
Cellular component	• nucleus • nucleoplasm • anaphase-promoting complex • cytoplasm • spindle • zeta DNA polymerase complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • regulation of cell growth • DNA repair • double-strand break repair • transcription, DNA-dependent • actin filament organization • mitosis • mitotic cell cycle spindle assembly checkpoint • negative regulation of epithelial to mesenchymal transition • negative regulation of transcription by competitive promoter binding • positive regulation of peptidyl-serine phosphorylation • negative regulation of protein catabolic process • DNA damage response, signal transduction resulting in transcription • negative regulation of sequence-specific DNA binding transcription factor activity • positive regulation of transcription, DNA-dependent • cell division • negative regulation of mitotic anaphase-promoting complex activity • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of cell-cell adhesion mediated by cadherin • negative regulation of transcription regulatory region DNA binding
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 10459 71890 Ensembl ENSG00000116670 ENSMUSG00000029003 UniProt Q9UI95 A2A7G8 RefSeq (mRNA) NM_001127325 NM_027985 RefSeq (protein) NP_001120797 NP_082261 Location (UCSC) Chr 1:
11.73 – 11.75 Mb Chr 4:
148.13 – 148.15 Mb PubMed search

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.