Acronym
- Magnetic anomaly detector, a scientific instrument and anti-submarine warfare detection device
- M.A.D., a fictional evil organization led by Dr. Claw from the cartoon series Inspector Gadget
- Make A Difference, an Indian NGO
- Mandibular advancement device, an appliance worn in the mouth to treat obstructive sleep apnea or snoring
- Market Abuse Directive, European company law on insider dealing and market manipulation
- Mastertronic's Added Dimension (or "Mastertronic Added Dimension"), a sub-label owned by defunct UK software publisher Mastertronic
- Mean absolute difference, a measure of statistical dispersion
- Median absolute deviation, a statistical measure of variability, more resistant to outliers than other measures
- Meg and Dia, American indie rock band
- Methodical Accelerator Design, a CERN scripting language for particle accelerator design and analysis of optics and beam dynamics.
- MAD (programming language), for Michigan Algorithm Decoder, a computer programming language
- MIFARE Application Directory, a data structure on MIFARE contactless chips
- Militärischer Abschirmdienst, the Military Counterintelligence division of the German Army
- Minimum absolute deviation, also known as Least absolute deviations
- Mothers against decapentaplegic, a protein of the SMAD family
- MPEG Audio Decoder, an audio decompression software
- Multi-conjugate Adaptive optics Demonstrator, astronomical method of using multiple guide stars and deformable mirrors to sense and correct for the distortions produced by turbulence in Earth's atmosphere
- Multi-wavelength anomalous dispersion, a technique used in X-ray crystallography
- Museum of Arts & Design, located in New York City
- Mutual assured destruction, a doctrine of military strategy
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